A Novel Multi-Stage Pressure-Responsive Glaucoma Valve Strip for Anterior Chamber Angle Implantation: A Futuristic Approach to Precision IOP Control

Abstract

This paper introduces a novel concept for surgical glaucoma management: a multi-valve implantable strip system designed for anterior chamber angle placement. The device comprises three micro-valves embedded within a biocompatible strip, each engineered to activate at specific intraocular pressure (IOP) thresholds (20–25 mmHg, 30–35 mmHg, and >50 mmHg). This graduated mechanism allows dynamic, staged aqueous outflow that mirrors physiological resistance, aiming to prevent both early hypotony and hypertensive spikes. The concept represents a step forward in personalized glaucoma therapy, with potential applications in both primary open-angle glaucoma and refractory cases. A prototype and preclinical validation roadmap are proposed.